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KMID : 0984720030350030154
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Infection and Chemotherapy
2003 Volume.35 No. 3 p.154 ~ p.159
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Eradication Rate of Lansoprazole-Based Triple Therapy in Peptic Ulcer Patients with helicobacer pylori and Efficacy of Urea Breath Test in Evaluating Helicobacter pylori Eradication
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Jung Hye-Kyung
Kwak Jae-Jin
Yu Min-A
Bae Ki-Sun
Kwon Jung-Mi
Lee Jong-Soo
Kim Do-Young
Moon Il-Hwan
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Abstract
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Background: There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication.
Methods: patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 mg b.d., and amoxicillin 1 g b.d. and clarithromycin 500 mg b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status.
Results: A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46).
Conclusion: Our study that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.
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KEYWORD
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helicobacter pylori, eradication, lansoprazole, urea breath test
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